Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nano-sheets as a potential copyright of cisplatin: equilibrium and release kinetics
Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nano-sheets as a potential copyright of cisplatin: equilibrium and release kinetics
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Advanced Liquid Lipstick silicate nano-sheets as exfoliated and separated layers were developed from natural glauconite and hybridized with methanol, producing a methoxy exfoliated structure (Mth/EXGL).The structure was assessed as an enhanced copyright of the cisplatin drug (CSPN) with significant loading, release, and cytotoxicity properties.The methoxy form of exfoliated glauconite showed better loading properties (327.
7 mg/g) than the exfoliated sample (202.4 mg/g) as well as the raw sample (119.3 mg/g).
This enhancement was assigned to the incorporated active loading centers after the methanol hybridization step, which is in agreement with the steric studies and determined active site density (Nm = 45.5 mg/g (Mth/EXGL), 38.4 mg/g (EXGL), and 26.
3 mg/g (glauconite).Moreover, each site across the interface of Mth/EXGL has the capacity to be loaded with 8 CSPN molecules, donating multi-molecular mechanisms and their loading in vertical Magnolia Bark orientation.The CSPN loading energy value (<8 kJ/mol) into Mth/EXGL reflected the dominant impact of the physical mechanisms, including electrostatic attractions and hydrogen bonding.
The recognized release profile demonstrates continuous and controlled behavior that can extend up to 110 h at pH 7.4 and 170 h at pH 5.5.
This releasing behavior is regulated by two main processes (diffusion and erosion) based on the release kinetic findings.Also, Mth/EXGL as a copyright of CSPN induces its cytotoxic effect on human cervical epithelial tumors (HeLa) (0.65% cell viability) as compared to the free form of CSPN (6.
6% cell viability).The Mth/EXGL is recommended as a delivery system for CSPN considering its determined loading, release, and cytotoxicity properties.